| functional annotation |
| function* |
zeta-chain (TCR) associated protein kinase 70kDa |
|
| GO BP* |
| GO:0043366 |
[list]
[network]
|
beta selection |
(2 genes) |
IEA |
| GO:0045059 |
[list]
[network]
|
positive thymic T cell selection |
(4 genes) |
IDA
|
| GO:0045060 |
[list]
[network]
|
negative thymic T cell selection |
(4 genes) |
IEA |
| GO:0046641 |
[list]
[network]
|
positive regulation of alpha-beta T cell proliferation |
(5 genes) |
IEA |
| GO:0046638 |
[list]
[network]
|
positive regulation of alpha-beta T cell differentiation |
(11 genes) |
IEA |
| GO:0050852 |
[list]
[network]
|
T cell receptor signaling pathway |
(11 genes) |
IEA |
| GO:0050850 |
[list]
[network]
|
positive regulation of calcium-mediated signaling |
(15 genes) |
IEA |
| GO:0018108 |
[list]
[network]
|
peptidyl-tyrosine phosphorylation |
(18 genes) |
IEA |
| GO:0046777 |
[list]
[network]
|
protein amino acid autophosphorylation |
(47 genes) |
IEA |
| GO:0007243 |
[list]
[network]
|
protein kinase cascade |
(285 genes) |
NAS
|
| GO:0006955 |
[list]
[network]
|
immune response |
(626 genes) |
IDA
|
|
|
| GO CC* |
| GO:0042101 |
[list]
[network]
|
T cell receptor complex |
(12 genes) |
IDA
|
| GO:0005730 |
[list]
[network]
|
nucleolus |
(505 genes) |
IDA
|
| GO:0005829 |
[list]
[network]
|
cytosol |
(886 genes) |
IEA EXP
|
| GO:0005634 |
[list]
[network]
|
nucleus |
(5159 genes) |
IDA
|
| GO:0005737 |
[list]
[network]
|
cytoplasm |
(7101 genes) |
TAS
|
|
|
| GO MF* |
| GO:0001784 |
[list]
[network]
|
phosphotyrosine binding |
(4 genes) |
IEA |
| GO:0004715 |
[list]
[network]
|
non-membrane spanning protein tyrosine kinase activity |
(40 genes) |
IEA |
| GO:0005524 |
[list]
[network]
|
ATP binding |
(1425 genes) |
NAS
|
| GO:0016740 |
[list]
[network]
|
transferase activity |
(1735 genes) |
IEA |
| GO:0000166 |
[list]
[network]
|
nucleotide binding |
(2167 genes) |
IEA |
| GO:0005515 |
[list]
[network]
|
protein binding |
(7230 genes) |
IPI
|
|
|
| KEGG* |
| hsa04650 |
Natural killer cell mediated cytotoxicity |
| hsa04660 |
T cell receptor signaling pathway |
| hsa05340 |
Primary immunodeficiency |
|
|
| orthologous |
[ortholog page]
Zap70(Mmu)
Zap70(Rno)
|
|
subcellular
localization* |
| cyto 5, cyto_nucl 3, cyto_pero 3 |
(prediction for NP_001070.2) |
| cyto 3, cyto_mito 2, nucl 1 |
(prediction for NP_997402.1) |
|
| gene coexpression |
network*for
coexpressed
genes |
| KEGG ID |
Title |
#genes |
Link to the KEGG map
(multiple genes) |
| hsa04660 |
T cell receptor signaling pathway |
6 |
 |
| hsa04650 |
Natural killer cell mediated cytotoxicity |
4 |
 |
| hsa04640 |
Hematopoietic cell lineage |
2 |
 |
| hsa04060 |
Cytokine-cytokine receptor interaction |
2 |
 |
Genes directly connected with ZAP70 on the network
| MR* |
Cor* |
symbol |
fuction |
coexpression
detail |
Entrez Gene ID |
| 2.8 |
0.73 |
LCK |
lymphocyte-specific protein tyrosine kinase |
[detail] |
3932 |
| 5.1 |
0.68 |
ITK |
IL2-inducible T-cell kinase |
[detail] |
3702 |
| 7.1 |
0.63 |
SEPT1 |
septin 1 |
[detail] |
1731 |
| 11.6 |
0.44 |
SKAP1 |
src kinase associated phosphoprotein 1 |
[detail] |
8631 |
| 13.6 |
0.54 |
MYO1G |
myosin IG |
[detail] |
64005 |
| 20.2 |
0.44 |
LOC158830 |
Uncharacterized protein LOC158830 |
[detail] |
158830 |
|
network*
in tissue |
|
coexpressed
gene list |
[coexpressed gene list for ZAP70]
|
| gene expression |
| all samples |
[expression pattern for all samples]
|
| tissue specificity* |
|
